![]() ![]() We highlight emerging chemical and computational technologies in FBDD and discuss strategies for optimising fragment hits. In this review, we describe our views on fragment library design, and on what constitutes a good fragment from a medicinal and computational chemistry perspective. However, good library design is essential to ensure optimal chemical and pharmacophore diversity, molecular complexity, and physicochemical characteristics. Since the number of possible molecules increases exponentially with molecular size, small fragment libraries allow for a proportionately greater coverage of their respective ‘chemical space’ compared with larger HTS libraries comprising larger molecules. Fragment hits can, therefore, serve as a more efficient start point for subsequent optimisation, particularly for hard‐to‐drug targets. Contrary to HTS, where large libraries of drug‐like molecules are screened, FBDD screens involve smaller and less complex molecules which, despite a low affinity to protein targets, display more ‘atom‐efficient’ binding interactions than larger molecules. ![]() Send us feedback about these examples.Fragment‐based drug discovery (FBDD) is now established as a complementary approach to high‐throughput screening (HTS). These examples are programmatically compiled from various online sources to illustrate current usage of the word 'sentence fragment.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. ![]() ![]() 2017 Even the emoluments clause, little more than a sentence fragment, gets more notice nowadays. 2020 Manuscript Writer constructs an introduction, for example, by pulling sentences and sentence fragments from a set of open-access references and laying them out in what appears to be no particular order. Tess Taylor, WSJ, Roger is partial to sentence fragments Antonia has to supply the rest. 2023 His final version ends on a sentence fragment-a dramatic reminder that arcadias may well be unfinishable. Recent Examples on the Web The text Wujing's man sent was a sentence fragment - a grammar faux pas that an exacting polyglot like Dembe would never make. ![]()
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